Genetically Engineered Mouse Hepatocytes

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Evaluate the utility of GEM models by prescreening with cryopreserved hepatocytes isolated from Taconic's t-ADMET portfolio mice. These products represent a convenient experimental tool to help design studies and interpret data performed with genetically-engineered mice. These cryopreserved cells are suitable for suspension incubations.

Applications:

  • Select in vivo models
  • Bridge between In vitro and in vivo studies
  • Enhance efficiency of GEM in vivo studies
  • Mechanistic drug metabolism studies


Humanized Liver CYP3A4 (Model 9048)

Cyp3a (8-gene) Knockout (Model 9011)

Humanized OATP1B1 (Model 10708)

Humanized OATP1B3 (Model 10725)

Humanized OATP1B1/1B3 (Model 115594)

Oatp1a/1b Cluster Knockout (Model 10707)