Dear Colleagues:

In Vitro ADMET Laboratories (IVAL) is proud to offer quality products and services for your in vitro ADMET studies.

Our flagship products consist of:

Cryopreserved hepatocytes: High quality cryopreserved human and animal hepatocytes in both suspension and plateable grades. These primary cells can be applied in drug uptake, metabolism, drug-drug interactions, and hepatotoxicity studies.

Cryopreserved enterocytes: We are the first to successfully isolate and cryopreserve human and animal enterocytes to retain drug metabolism activities. IVAL’s enterocytes can be utilized to evaluate intestinal metabolism of orally-administered drugs as well as drug-drug and food-drug interactions in the intestines.

IVAL’s latest innovation:

MetMax™ Hepatocytes and MetMax™ Enterocytes (Patent Pending): Permeabilized, co-factor supplemented hepatocytes and enterocytes. MetMax™ cells can be used directly after thawing; do not require centrifugation and microscopic quantification of cell viability and cell number, thereby allowing convenient application for routine hepatic metabolism and hepatic drug-drug interaction studies.

Our contract research services include: metabolic stability, metabolite profiling, metabolic phenotyping, P450 inhibition, and P450 induction studies. The following are examples of our proprietary technologies:

ROS/ATP human hepatocyte assay to identify sDILI drugs: This proprietary assay was co-developed with FDA National Center for Toxicological Research. The assay could identify (with >85% specificity and sensitivity) drugs that are known to be associated with severe liver toxicity, leading to deaths or a need for liver transplantation.

Plated hepatocyte relay assay for slowly metabolized chemicals: This patented assay allows in vitro study of drugs with low hepatic clearance that cannot be readily evaluated with routine in vitro approaches. In this assay, compounds are incubated for 24 hrs with plated hepatocytes, with the incubated media transferred to newly plated hepatocyte cultures daily. Time-dependent parent disappearance is analyzed against model chemicals for up to 120 hrs (5 days), with the calculated hepatic intrinsic clearance similar to that observed in vivo.

Integrated Discrete Multiple Organ Co-culture (IdMOC™): This patented experimental system co-cultures cells from multiple organs. The cells are physically separated (discrete) but interconnected (integrated) by an overlying. IdMOC™ models the human/animal in vivo, and allows the evaluation of organ-specific toxicity in the presence of multiple organ metabolism.

We strive to be the best in our field: best products, best service, best science, best customer support.

With my best regards,

Albert P. Li, PhD, MBA

President and CEO

In Vitro ADMET Laboratories, Inc