Ancillary Meeting:  12th International ISSX Meeting in Portland, Oregon

Integrating Human Intestinal Mucosa, Intestinal Microbiome, and Human Hepatocytes in the Assessment of Human Drug Properties.

Inaugural Hepatic and Enteric Research Organizations (HERO) Workshop

Monday, July 29, 2019 (17:45 – 19:45), Portland Ballroom 254-257

Synopsis:  

Oral delivery is the preferred route of drug administration.  An orally administered drug is firstly subjected to metabolism by the enterocytes in the intestinal mucosa and the intestinal microbiome in the intestinal lumen, followed by metabolism by the hepatocytes in the liver upon absorption into the portal circulation.   Accurate assessment of in vivo drug properties therefore will require a clear understanding of the combined roles of enteric and hepatic drug metabolism.   In vitro and in vivo experimental approaches that are well-established for the elucidation of the roles of hepatic drug metabolism on drug disposition, drug-drug interactions, and drug toxicity, should therefore be applied towards enteric drug metabolism.   The presentations in this Inaugural HERO workshop serve to communicate the latest findings in experimental approaches to evaluate enteric drug metabolism, and the application of enteric data in concert with hepatic data in the assessment of in vivo drug properties.

Agenda

  • 17:45 – 18:00:  Welcoming Remarks (Al Li):  Mission of HERO
  • 18:00 – 18:20:  PBPK analysis for the prediction of in vivo drug disposition involving enteric and hepatic drug metabolism, uptake and efflux (Yuichi Sugiyama; Riken Institute)
  • 18:20 – 18:40:  A comparison of hepatic and enteric drug metabolism using cryopreserved human hepatocytes and cryopreserved human intestinal mucosa (Al Li, In Vitro ADMET Laboratories Inc.)
  • 18:40 – 19:00:  Translational approaches to assess pharmacokinetic herb-drug interactions (Mary Paine, Washington State University)
  • 19:00 – 19:20:  Quantitative importance of enteric UGTs in drug absorption and disposition (Bhagwat Prasad; University of Washington)
  • 19:20 – 19:40:  Understanding the physiological, pharmacological, and toxicological functions of the host xenobiotic-sensing nuclear receptors on gut microbiome using mouse models (Julia Cui, University of Washington)
  • 19:40 – 19:45:  Closing remarks (Al Li)

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